新英格兰医学杂志：生活方式改变和活动性对患有2型糖尿病肥胖成人的影响

NEJM：Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes

新英格兰医学杂志的一篇研究报道，减轻体重并适度运动可减缓超重2型糖尿病患者运动机能的衰退。研究人员随机将5145名45-74岁的2型糖尿病超重或肥胖成人患者分成两组，分别接受强化生活方式干预或糖尿病支持和教育程序治疗。5016名受试者的数据结果显示，4年的不同干预后，生活方式干预组的2514名成人中，517 名(20.6%)严重失能而有969(38.5%)名受试者运动功能良好；支持疗法的2502名受试者中这一数据分别为656名(26.2%) 以及798名(31.9%)。与支持疗法组患者相比，生活方式干预组运动失能的危险系数的相对减少值为48% (优势比, 0.52; 95% 置信区间, 0.44至0.63; P<0.001)。

A study published in NEJM reported that weight loss and improved fitness slowed the decline in mobility in overweight adults with type 2 diabetes. Researchers randomly assigned 5145 overweight or obese adults be-tween the ages of 45 and 74 years with type 2 diabetes to either an intensive lifestyle intervention or a diabetes support-and-education program and 5016 participants contributed data. At year 4, among 2514 adults in the lifestyle-intervention group, 517 (20.6%) had severe disability and 969 (38.5%) had good mobility; the numbers among 2502 participants in the support group were 656 (26.2%) and 798 (31.9%), respectively. The lifestyle-intervention group had a relative reduction of 48% in the risk of loss of mobility, as compared with the support group. Both weight loss and improved fitness were significant mediators of this effect.

（注：生活方式干预包括饮食校正、增加体力活动（PA）等）

详见：http://www.nejm.org/doi/full/10.1056/NEJMoa1110294